Mentor

Sadis Matalon, Ph.D.
Professor

Department of Anesthesiology

Mailing address:

BMR2 222

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2172

Telephone: (205) 934-4231

Fax: (205) 934-7476

Two Postdoctoral Positions Available

Two full time postdoctoral positions are available immediately as part of a recently NIH funded proposal to study the basic mechanisms by which chlorine gas damages the pulmonary system and develop effective countermeasures. Primary area of research include mechanisms of inhibition of surfactant synthesis and secretion, ion transport as well as innate immunity by chlorine gas and reactive intermediates formed by its by-products and reactive oxygen-nitrogen intermediates. The successful candidates will be part of a multidisciplinary group consisting of investigators in the Department of Anesthesiology (Drs. Matalon, Ji and McArdle), Environmental Health Sciences (Dr. Postlethwait and Swuadrito) and Medicine (Drs. Abraham and Johnson) and will receive interdisciplinary training in reactive species biochemistry, cellular and molecular and physiological aspects of ion transport, or surfactant biochemistry and assessment of post-translational modification of lung proteins with 2d gel and mass spectrometry analysis. The investigators are active members of the world re-known Center for Free Radical Research, which includes researchers from the Departments of Pathology, Surgery, Anesthesiology, Medicine, Environmental Health Sciences, Nutrition and Biochemistry. This is a highly interactive research group with well over thirty postdoctoral fellows.

The positions are available immediately. Initial appointment will be for one year, with renewal on a year-to-year basis for up to four years. Renewal of appointment is contingent on performance and availability of funds. The positions include outstanding compensation and benefits (including paid vacations and free health insurance and some compensation for relocation expenses. Minimum qualifications include a Ph.D. (or equivalent) in Biological or Physical Sciences with at least one year of relevant experience and outstanding references.

The University of Alabama at Birmingham is an equal opportunity, affirmative action employer with a strong commitment to ethnic and cultural diversity among its faculty, students, and administrative staff. Applications from women and ethnic minorities are encouraged.

Please send a CV and cover letter along with three references to:
Dr. Sadis Matalon

Mentor

Igor Chesnokov, Ph.D.
Assistant Professor

Mailing address:

DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR GENETICS

KAUL 552A

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0024

Telephone: (205) 934-6974

Fax: (205) 975-2188

E-mail: ichesnokov@uab.edu

Postdoctoral Position Available

Postdoctoral position is available to study the mechanisms and regulation of the initiation of DNA replication and cell cycle progression in Drosophila. Motivated candidates with strong background in Molecular and/or Cell Biology are encouraged to apply. Knowledge of Drosophila molecular genetics is required. Send resume and the names of three references to:

ichesnokov@uab.edu

Biochemistry &

Molecular Genetics

Mentor

Natalia Kedishvili, Ph.D.
Assistant Professor

 Mailing address:

KAUL 440B

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0024

 Telephone: (205) 996-4023

 E-mail:nkedishvili@uab.edu

A Post-Doctoral position is available to study the functions of human and rodent short-chain dehydrogenases/reductases in retinoid and steroid metabolism using ex vivo living skin raft culture model and in vivo mouse transgenic models. Experience in molecular biology, cell biology and protein biochemistry and handling of mice is desirable. Salary commensurate with experience. To inquire, please contact Dr. Natalia Kedishvili, nkedishvili@uab.edu, 205-996-4023, at the University of Alabama, Birmingham, USA.

Mentor

 Trygve Tollefsbol, Ph.D.
Associate Professor

 Mailing address:

CH 175A

1530 3RD AVENUE S

BIRMINGHAM AL 35294-1170

 Telephone: (205) 934-4573

Fax: (205) 975-6097

 E-mail:Trygve@uab.edu

Mentor

Xincheng Yao, Ph.D.
Assistant Professor

 Mailing address:

SHEL 805

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

 Telephone: (205) 996-7459

Fax: (205) 975-4919

E-mail: xcy@uab.edu

Postdoctoral Researcher Position in Biomedical Optics

Description:

A postdoctoral position is available immediately in Biomedical Imaging group in the Department of Biomedical Engineering, University of Alabama at Birmingham. We are developing fast functional optical coherence tomography (OCT) and confocal microscopy for optical imaging of retinal function utilizing transient intrinsic optical responses associated with neural activities. The postdoctoral researcher is primarily responsible for development of optoelectonic instrumentations for retinal imaging, but may be also involved in other research activities, e.g. optical tweezers and cell spectroscopy. The candidate would have excellent opportunities to interact with researchers in Engineering, Neurophysiology, and Vision Science for a multi- & interdisciplinary research training.

Qualification:

The successful candidate should have a Ph.D. degree in Biomedical Engineering, Physics, Optics, Electronics, or other related disciplines. Demonstrated excellence in one or more of the following areas is required: OCT, confocal microscopy, optical tweezers, laser spectroscopy, light spatial modulator, polarization measurement, retinal imaging, and neuroscience. Proficiency in programming using IDL, Labview, Matlab is plus. Self motivation and creativity are highly desirable.

Interested applicants should send application materials to Dr. Xincheng Yao via email. The application materials should include: a brief summary of research accomplishments, interests and background, a current CV with names and contact information of at least three references and a brief statement of career goals.

Mentor

Dr. Yuhua Song
Assistant Professor

 Mailing address:

SHEL 803

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

 Telephone: (205) 996-6939

Fax: (205) 975-4919

E-mail: yhsong@uab.edu

Mentor

David B. Allison, Ph.D.
Statistical Genetics

Department of Biostatistics

Mailing address:

RPHB 327

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0022

Telephone: (205) 975-9169

Fax: (205) 975-2540

E-mail: dallison@uab.edu

Cardiovascular
Disease

Mentor

Suzanne Oparil, M.D.
Program Director and Professor
UAB Hypertension Program

 Mailing address:

UAB Hypertension Program

ZRB 1034

1530 3RD AVENUE SOUTH

BIRMINGHAM AL 35294-0007

 Telephone:
(205) 934-2580

Fax: (205) 975-5119

 E-mail: soparil@uab.edu

Cell Biology

Mentor

Guillermo Marques, Ph.D.
Assistant Professor

Depts. of Cell Biology and Neurobiology

School of Medicine & Dentistry

 Mailing address:

MCLM 670

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0005

 Telephone:
(205) 975-8851

E-mail: gmarques@uab.edu

Mentors

Louis J. Dell'Italia, M.D.

Ahsan Husain, Ph.D.

Professor and Director

Center for Heart Failure Research

Mailing address:

BMR2 432

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2180

Tel: (205) 934-3969

Fax: (205) 996-2586

E-mail : pia@uab.edu

Postdoctoral Positions Available

The UAB Center for Heart Failure Research (CHFR) and NIH funded Specialized Center of Clinically Oriented Research (SCCOR) in Cardiac Dysfunction has multiple postdoctoral opportunities. Areas of study include regenerative growth of the heart, structural basis of function in enzymes, fibroblast-cardiomyocyte interactions in volume and pressure overload, cardiomyocyte signaling mechanisms in heart failure. The CHFR has multiple state of the art core facilities including high resolution mouse echo-doppler imaging and hemodynamics, microscopy, HPLC/mass spectroscopy analysis of neurohormones and reactive oxygen species.

If interested, please submit your CV and references to:

pia@uab.edu

Mentor

John D. Mountz, MD, PhD

Professor of Medicine

Department of Medicine

Division of Clinical Immunology & Rheumatology

Mailing address:

LHRB 473A

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0007

Telephone: (205) 934-8909

Fax: (205) 975-6648

E-mail: jdmountz@uab.edu

Postdoctoral Positions Available

A postdoctoral position is available for studies of pathogenic mechanisms of autoimmune disease including mouse models and human studies of rheumatoid arthritis and SLE.

My laboratory is analyzing the pathogenic mechanisms of autoreactive T cells and autoantibodies produced by B cells in mice and humans. We have characterized a novel BXD2 mouse model of autoimmune disease, which exhibits in vivo spontaneous activation of CD4 T cells. This results in increased development of Th-IL-17 CD4 T cells that induce high expression of activation-induced cytidine deaminase (AID) in B cells. This leads to production of multireactive pathogenic autoAbs that can transfer both glomerulonephritis and arthritis.

Successful applicants should have a Ph.D. or M.D. degree and at least one year of experience in cellular immunology and molecular biology with particular emphasis on mouse models of autoimmune disease. U.S. citizens with permanent residency will be given priority. International students will be considered only with outstanding skills in verbal and written English and one first-author paper.

Applicants should submit a letter of interest containing addresses, telephone numbers, citizenship status, names and contact information of three references. a CV with publication record and/or thesis topic, and a one-page statement of interest to John D. Mountz, MD, PhD via email: jdmountz@uab.edu

www.uab.edu/rheumatology

www.uab.edu/arthritis

www.uab.edu/immunology

http://info.dom.uab.edu/rheum/FacultyandadminFACULTYMountz.htm

Mentor

Huang-Ge Zhang, MD, DVM, PhD

Associate Professor of Medicine

Department of Medicine

Division of Clinical Immunology & Rheumatology

Mailing address:

Shelby 306

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

Telephone: (205) 975-9940

Fax: (205) 975-6788

E-mail: huang-ge.zhang@ccc.uab.edu

Postdoctoral Positions Available

Postdoctoral positions are available in the laboratory of Dr. Huang-Ge Zhang to study tumor exosome-mediated immunosuppression and COP9-regulated cell cycling. Highly motivated candidates with a strong background in immunology, cellular biology, or related fields should apply. Expertise in molecular immunology is essential. Expertise in proteomics technology is a plus.

Salary is commensurate with experience. International and J-1 visa candidates welcome. Qualified individuals with a recent Ph.D., M.D., or equivalent degree are invited to submit, via e-mail, their curriculum vitae, names and contact information for three (3) references (with e-mail addresses, if possible), and a letter describing your research interests to Huang-Ge Zhang, Ph.D.

www.uab.edu/rheumatology

www.uab.edu/arthritis

www.uab.edu/immunology

http://info.dom.uab.edu/rheum/FacultyandadminFACULTYZhang.htm

Mentor/Principal Investigator

David B. Allison, Ph.D.
Professor & Head

Section on Statistical Genetics

Department of Biostatistics and Clinical Nutrition Research Center (CNRC)

 Mailing address:

RPHB 327

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0022

 Telephone:
(205) 975-9169

Fax: (205) 975-2540

 E-mail:Dallison@uab.edu

Mentor/Principal Investigator

Craig Elmets, Ph.D.
Professor/Chairman

Department of Dermatology

 Mailing address:

EFH 414

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0009

 Tel: (205) 975-6415

Fax: (205) 934-5766

E-mail: celmets@uab.edu

Mentor/Principal Investigator

Santosh K. Katiyar, Ph.D.
Associate Professor

Department of Dermatology

 Mailing address:

VH 557

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0019

 Tel: (205) 975-2608

Fax: (205) 975-5745

E-mail: skatiyar@uab.edu

Postdoctoral Positions Available

Job Description: The accomplishment of the project work related to "Chemoprevention of cancer by naturally occurring botanical supplements or antioxidants" using cell culture and animal models. This will include the investigation of the causes, mechanisms and preventive approaches for cancer. This work will require experience in cell culture, animal handling, plus basic biochemistry/chemistry and molecular biology techniques such as Western, Northern, RT/PCR techniques and immunohistochemistry. Responsibilities will include design and execution of experimental procedures, the maintenance of complete laboratory records of experiements, the preparation of manuscripts suitable for publication and presentations at internal and external venues as required.

Position Requirements: Applicants should have experience in carcinogenesis, their causes, mechanisms and chemopreventive approaches. In addition to experience the researchers should have interest and a clear vision of future progress in cancer mechanisms and their prevention.

Applicants should send curriculum vitae with a description of research interests and names of three references with email addresses to: Santosh K. Katiyar, Ph.D.

Mentor/Principal Investigator

Max D. Cooper, M.D.
Director of Immunology Training Program

Harry W. Schroeder, Jr., M.D., Ph.D.
Associate Director of
Immunology Training Program

Division of Developmental
and Clinical Immunology

 Mailing address:

SHEL 401

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

 Telephone: (205) 934-1522

Fax: (205) 975-6352

 E-mail: hwsj@uab.edu

Mentor/Principal Investigator

Randall S. Davis, M.D.
Assistant Professor

Division of Developmental
and Clinical Immunology

 Mailing address:

SHEL 412

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

 Telephone: (205) 934-2512

Fax: (205) 975-7218

 E-mail: randall.davis@ccc.uab.edu

Postdoctoral Fellowship at the University of Alabama at Birmingham

A postdoctoral position in the UAB Division of Developmental and Clinical Immunology is immediately available to study members of a novel family of Ig-like receptors expressed by B cells and B lineage lymphoproliferative disorders. The project will focus on exploring cellular expression pattterns and tyrosine-based signaling capacity in normal and malignant B cells.

A strong background in basic cellular immunobiology and signal transduction is necessary. Familiarity with molecular biology, flow cytometry, and biochemistry techniques are required. Suitable candidates should be able to communicate well verbally and work independently.

Ph.D. and/or M.D. degree is required. Applicants please send curriculum vitae with a description of research interests and names of three references with email addresses to: Randall S. Davis, M.D.

Mentor

Xiangyi Lu, Ph.D.
Research Associate Professor

Environmental Health Sciences

 Mailing address:

RPHB 623A

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0022

Telephone: (205) 934-7043

Fax: (205) 975-6341

 E-mail : xlu@uab.edu

Mentor

Rui-Ming Liu, M.D., Ph.D.
Associate Professor

Environmental Health Sciences

 Mailing address:

RPHB 534

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0022

Telephone: (205) 934-7028

Fax: (205) 975-6341

 E-mail : rliu@uab.edu

Postdoctoral Fellow Position Available

Our major interest is the role of oxidative stress/antioxidant in aging and diseases. Specifically, we are interested in molecular mechanisms underlying the protective effects of antioxidants including glutathione, the most abundant intracellular free thiol and an important antioxidant, in lung fibrotic disease and neurodegerative diseases such as Alzheimer. Research involves transgenic and knockout mouse models as well as cell culture. Candidates must have a PH.D. in cell biology, biochemistry, or a related discipline. Basic knowledge and techniques in molecular biology is required. Knowledge of oxidative stress/antioxidant defense is preferred. Please send you cover letter and CV by email to Dr. Rui-Ming Liu.

Environmental
Health Sciences

Mentor

 Douglas M. Ruden, Ph.D.
Associate Professor

Environmental Health Sciences

 Mailing address:

RPHB 630

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0022

Telephone: (205) 934-7042

Fax: (205) 975-6341

 E-mail : douglasr@uab.edu

Environmental
Health Sciences

Mentor

 Edward M. Postlethwait, Ph.D.
Research Instructor

Mailing address:

RPHB 530

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0022

Telephone: (205) 934-7212

Fax: (205) 975-6341

Contact:

Carol A. Ballinger, Ph.D.

 E-mail: caball@uab.edu

Genetics

Division of Genetic and Translational Medicine

Mentor

Kai Jiao, M.D., Ph.D.
Assistant Professor

Mailing address:

KAUL 768

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0024

 Telephone: (205) 996-4198

E-mail: kjiao@heflingenetics.uab.edu

Mentor

Jere P. Segrest, M.D.
Professor

Mailing address:

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0012

 Telephone: (205) 934-4070

Fax: (205) 975-8079

E-mail : segrest@uab.edu

Postdoctoral Fellowships Available

Physics-based computational biologist sought to probe detailed molecular structures of apolipoprotein (apo) A-I on high density lipoprotein (HDL). Focus is on pathways for in vivo assembly of cholesteryl ester (CE)-rich (spheroidal) HDL, including the structure/dynamics of phospholipid (PL)-poor (preß) and PL-rich (discoidal) HDL. The driving hypothesis is that apoA-I is a uniquely elastic lipid-clamp capable of absorbing PL and CE in increments of a few molecules at a time. Because of a recent demonstration by our lab of the power of MD simulations to provide supramolecular images of HDL, MD simulations combined with experimental approaches uniquely position us to gain fundamental new insights into the structure/function of HDL subspecies. Candidates should have obtained a PH.D. within the past 3 years with a strong background in molecular modeling/dynamics. A highly motivated and independent scientist able to work within an interdisciplinary team is preferred. E-mail research summary, CV, and 3 references to : Jere P. Segrest: segrest@uab.edu

http://www.aru.uab.edu

Program Director

Richard Sims, M.D.
Associate Professor
E-mail: rsims@aging.uab.edu

Mailing address:

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2041

 Telephone: (205) 934-9261

Fax: (205) 934-7354

 Contacts:

E-mail: Bosworth@uab.edu

Fellowships Available
Post Graduate Fellowships in Geriatric Medicine

The Southeast Center for Excellence in Geriatric Medicine is a collaborative venture of the University of Alabama at Birmingham (UAB) and Emory University in Atlanta under the direction of Joseph G. Ouslander, M.D. (Emory) and Richard M. Allman, M.D. (UAB). The Center is funded by a grant from The John A. Hartford Foundation and by matching institutional funds from Emory, Wesley Woods, and UAB. The Center provides advanced training for physicians preparing for careers in Geriatric Medicine.

The Center capitalized on the proximity, mutual areas of research expertise, and other synergistic collaborations that enhance the capabilities of both programs to serve the educational needs of young physicians interested in careers in academic Geriatric Medicine, and to provide them with the expetise, mentorship, and environment they need for success.

In addition to providing training and support for senior Geriatric Medicine felllows and junior faculty, the Center seeks to foster inter-institutional research programs that capitalize on already existing mutual interests and expertise.

Program

Fellows enroll in the accredited Geriatric Medicine training program at Emory or UAB. Individually customized training curricula will allow fellows to select the most appropriate course of clinical, academic, and research training experiences within the essential framework required for board certification. Fellowship training opportunities include:

ACCREDITATION

Both Fellowship Programs are accredited by the Accreditation Council for Graduate Medical Education (ACGME).

The University of Alabama at Birmingham and Emory University administer their educational program and activities inculding admissions without regard to race, color, religion, sex, national origin, handicap or Vietname era or disable veteran status. (Title IX of the Education Amemdments of 1972 specifically prohibits discrimination on the basis of sex.)

For more information and/or an application contact Peter Bosworth, Program Administrator.

Mentor/Principal Investigator

Scott W. Blume, M.D.
Assistant Professor

 Mailing address:

WTI 508

1530 3RD AVENUE S

BIRMINGHAM AL 35294-3300

 Telephone: (205) 975-2409

E-mail: scott.blume@ccc.uab.edu

Postdoctoral Position Available

Our lab is investigating mechanisms of specific regulation of gene expression at the translational (RNA to protein) level. This work focuses on 5'-untranslated sequences that serve essentially as "RNA promoters" and sequence-specific RNA-binding proteins that control the efficiency of translation initiation. Our major gene of interest is IGF1R, a protooncogene with powerful mitogenic and anti-apoptotic capabilities, which is directly implicated in human breast cancer pathogenesis. This research includes a detailed examination of the IGF1R internal ribosomal entry site (IRES) which recruits the 40S ribosomal subunit to the vicinity of the translation initiation codon. We are also examining how these translational control mechanisms may be pathologically altered in human breast tumor cells.

One postdoctoral position is available to work on this project, which is sponsored by the NIH/National Cancer Institute. Applicants should have a Ph.D., D.V.M., M.D., or equivalent degree, and background/experience in molecular biology is desirable. Please e-mail your curriculum vitae, a brief statement of research interests, and names and contact information for three references to Dr. Scott Blume.

Mentor

John C. Kappes, Ph.D.
Associate Professor, Depts of Medicine, Microbiology and Pathology

 Mailing address:

LHRB 613

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0007

 E-mail: kappesjc@uab.edu

Postdoctoral Position Available

A postdoctoral research position to study HIV-1 molecular virology is immediately available in the laboratory of Dr. John Kappes, in the Department of Medicine at the University of Alabama at Birmingham.  The position is part of a recently funded three year project to study basic molecular mechanisms that mediate interaction between the HIV-1 reverse transcriptase (RT) polypeptide subunits p51 and p66.  The principal long-term goal of the project is to elucidate whether HIV-1 replication can be inhibited with small molecules that target RT subunit interactions.  This innovative work represents a novel therapeutic drug design approach for the treatment of HIV/AIDS.  The successful candidate will be part of a multidisciplinary HIV/AIDS research group, and the UAB Center for AIDS Research. 

Interested applicants should send application materials to Dr. Kappes by email.  The application materials should include a brief summary of research interests, a brief statement of career goals, a current CV, and the names and contact information of three references.  The postdoctoral position offers competitive compensation and benefits. More information on postdoctoral education at UAB can be found at http://www.postdocs.uab.edu.

Mentor/Principal Investigator

David T. Curiel, M.D., Ph.D., Director
Division of Human Gene Therapy

 Mailing address:

BMR2, Room 508

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2172

E-mail: curiel@uab.edu

Co-Mentors/Principal Investigators

Kenneth G. Saag, M.D., MSc.
Associate Professor of Medicine
Director, UAB CERTs

 Mailing address:

FOT 820D

1530 3RD AVENUE S

BIRMINGHAM AL 35294-3408

 Telephone: (205) 249-7746

Fax: (205) 975-6859

E-mail: ksaag@uab.edu

Jeffrey R. Curtis, M.D., M.P.H.
Assistant Professor of Medicine
Associate Director, UAB CERTs

Mailing address:

FOT 840

1530 3RD AVENUE S

BIRMINGHAM AL 35294-3408

Telephone: (205) 937-0585

Fax: (205) 975-6859

E-mail: jcurtis@uab.edu

Postdoctoral Clinical Research Fellowship Available
Center for Education & Research on Therapeutics in Musculoskeletal Disorders (CERTs)

Do you want better preparation for a career in clinical research within academic medicine? The UAB Center for Education and Research for Therapeutics on Musculoskeletal Disorders is sponsoring a postdoctoral clinical research fellowship (distinct from the UAB clinical rheumatology fellowship). Candidates should have a strong interest in epidemiology, outcomes and health services research, biostatistics, or related disciplines. Applicants should possess M.D. or Ph.D. degree, have excellent interpersonal skills and be fluent in written and spoken English. Past clinical training in musculoskeletal disorders is highly desirable. A graduate degree in public health (e.g. MPH, MS, MSPH) desirable, but not required.

Position provides mentored training with an opportunity to develop research skills and collaborate with a dynamic group of faculty and staff. The position will be a 1 year appointment with a flexible start date, competitive salary, excellent resources for career development (funding for conference travel, etc), and standard University beneftis. Fellow will have the opportunity to participate in studies funded by AHRQ, NIH, FDA, voluntary organizations and research foundations. Fellow will serve on project teams, implement research protocols, participate in data management/analysis procedures, report preparation and career development activities. Fellow also will participate in the grant writing and will share in authorship and investigator status in a manner commensurate with their effort and responsibilities. International and J-1 visa candidates welcome.

www.uab.edu/rheumatology

www.uab.edu/arthritis

Immunology/
Rheumatology

Mentor/Principal Investigator

 Robert P. Kimberly, M.D.
Professor

 Mailing address:

THT 429

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0006

 Telephone: (205) 934-5306

 E-mail: rpk@uab.edu

Immunology/
Rheumatology

Mentor/Principal Investigator

 Robert P. Kimberly, M.D.
Professor

 Mailing address:

THT 429

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0006

 Telephone: (205) 934-5306

 E-mail: rpk@uab.edu

Immunology/
Rheumatology

Mentor/Principal Investigator

 Robert P. Kimberly, M.D.
Professor

 Mailing address:

THT 429

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0006

 Telephone: (205) 934-5306

 E-mail: rpk@uab.edu

Mentor/Principal Investigator

Jon-Eun Kim, Ph.D.
Research Asst. Professor

 Mailing address:

BEC 330A

1530 3RD AVENUE S

BIRMINGHAM AL 35294-4440

 Telephone: (205) 975-5889

Fax: (205) 975-7217

 E-mail: jkim@uab.ed

Postdoctoral Position Available

The Department of Mechanical Engineering at the University of Alabama at Birmingham is seeking a postdoctoral fellow. The CSM (Computational Structural Mechanics) group in Computational Simulation Laboratory studies a wide spectrum of fields related to computational mechanics including structural mechanics and dynamics, fluid structure interactions and multidisciplinary design optimization. The application areas are injury biomechanics, vehicle crashworthiness, aeroelastic analyses, and topology/shape/size optimization of ground/flight vehicles.
Successful candidate for the postdoctoral fellow will hold a Ph.D with advanced training in injury biomechanics by vehicle crashworthiness. Experience with multibody dynamic analysis using MADYMO software would be highly desirable.
Responsibilities of the postdoctoral fellow include: assisting a current research project (modeling and simulation, and data analysis) and writing project reports and journal articles. This is a 3-year end date position.

Mentor/Principal Investigator

David L. Littlefield, Ph.D.
Professor

 Mailing address:

BEC 257

1530 3RD AVENUE S

BIRMINGHAM AL 35294-4461

 Telephone: (205) 934-8460

Fax: (205) 975-7217

 E-mail: khazlewood@uab.edu

Postdoctoral Position Available

A postdoctoral position is available to conduct analysis and research in computational structural mechanics (CSM) to support a number of ongoing projects, including error estimation and adaptivity for CSM applications, anisotropic damage and failure modeling, and methods for coupling multi-material Eulerian with Lagrangian meshes.

A Ph.D. degree in mechanics, mathematics or related field is required for the postdoctoral position. U.S. citizenship is also required. Preferred qualifications include experience in scientific computing and computational engineering applied to solid and structural mechanics applications. Familiarity with one or more of the following areas is also an advantage: mechanics of contact/impact, damage and failure mechanics, error estimation, fluid-structure interaction, updated Lagrangian and multi-material Eulerian formulations.

Interested applicants should send a resume, brief statement of research interests, and names of at least three references to:

Kim Hazelwood, Business Officer

E-mail: khazlewood@uab.edu

Medicine

Pulmonary, Allergy and

Critical Care Medicine

Mentor/Principal Investigator

Chad Steele, Ph.D.
Associate Professor

Mailing address:

THT - Pulmonary

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0006

 Telephone: 205- 996-9598

Fax: 205-934-1721

Email: chadsteele@uab.edu

Postdoctoral Positions Available

Two post-doctoral positions available to investigate (1) immunity to fungal pathogens of the lung and (2) regulation of Gram-negative bacterium-induced lung inflammation and injury. The first position will investigate aspects of lung host defense against the fungal pathogens Pneumocystis carinii and Aspergillus fumigatus. Primary studies will involve characterizing the role of the beta-glucan receptor Dectin-1 in macrophage and dendritic cell responses to both organisms. Other studies involve investigating specific tyrosine kinases and PI3K isoforms in innate defense as well as the role of STAT transcription factors in immunity against P. carinii and A. fumigatus. The second position will characterize mechanisms of gamma delta T cell-mediated regulation of lung inflammation and acute lung injury during Pseudomonas aeruginosa lung infection. All projects heavily involve working with mice.

Experience: Ph.D. in a basic science, Microbiology, Immunology or Cell Biology preferred. Experience with working with animals (injections, inoculations, tissue isolation and processing), RNA isolation (from small cell populations), real-time PCR, flow cytometry including sorting and cell culture is desired/required.

Other information:
My laboratory is new to UAB, thus the anticipated start date of these positions will be September/October 2007. Please e-mail CV to chadsteele@uab.edu and include 3 references.

Mentor/Principal Investigator

Sunnie R. Thompson, Ph.D.
Assistant Professor

Mailing address:

BBRB 466

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2170

 Telephone: 205- 996-7101

Email: sunnie@uab.edu

Postdoctoral Position Available

Our laboratory is primarily interested in understanding viral and host cell interactions during viral amplification. A postdoctoral position is available to study molecular mechanisms of viral translation and replication using both genetic and bioinformatics approaches. Experience in at least one of the following is preferred: yeast genetics, virology, or molecular biology techniques. Applicants should have demonstrated scientific productivity, good interpersonal and communication skills, and be able to conduct independent research.

Please send a copy of your CV, a brief statement of research interest, list of publications, and the names and contact information for three references to Dr. Sunnie Thompson.

Mentor/Principal Investigator

Louis B. Justement, Ph.D.
Associate Director
Medical Scientist Training Program

Mailing address:

SHEL 502

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

 Telephone: 205- 934-1429

Fax: 205-934-1875

E-mail: lbjust@uab.edu

Postdoctoral Position Available

Analysis of the Molecular and Functional Role
of the Adaptor Protein HSH2

Studies are ongoing to elucidate the functional role that the adaptor protein HSH2 plays in regulating B cell biology. HSH2 is selectively expressed in cells of the B lineage and its expression is up-regulated in response to agonists that promote B cell survival and differentiation, including CD40L, BLyS, LPS and CpG DNA. Studies have demonstrated that HSH2 is able to block BCR-induced apoptosis in the WEHI-231 B cell line, suggesting that this adaptor is expressed as part of a pro-survival program that is triggered by a range of stimuli. Although HSH2 has been shown to block mitochondrial depolarization in WEHI-231 cells in response to BCR cross-linking, it has little effect on BCR-proximal signaling. Interestingly, HSH2 has been found to interact with the mitochondrial outer membrane protein HAX-1, which has also been shown to function as a pro-survival protein. Thus, it is possible that HSH2 is involved in regulating distal signal transduction processes that control mitochondrial stability. Recent studies using transgenic mice have revealed that HSH2 does indeed play a critical role in regulating terminal differentiation of B cells into antibody secreting plasma cells. Based on these observations, it is likely that HSH2 is involved in regulating the survival and differentiation of B cells. Future studies will be conducted to:

1) Identify important regions/motifs of HSH2 that are involved in its pro-survival function

2) Identify the proteins that interact with HSH2 in B lymphocytes and assess their functional importance

3) Generate transgenic and conditional knockout mice to examine the importance of HSH2 in regulation of B cell development, activation and differentiation

Publications:

1. Herrin, B.R., Groeger, A.L., and Justement, L.B. The Adaptor Protein HSH2 Attenuates Apoptosis in Response to Ligation of the BCR Complex on the B Lymphoma Cell Line, WEHI-231. J. Biol. Chem. 280: 3507; 2005.

2. Herrin, B.R., and Justement, L.B. Expression of the Adaptor Protein HSH2 is Upregulated in Response to Stimuli that Promote Survival and Differentiation of B Cells. J. Immunol. 176: 4163; 2006.

Mentor/Principal Investigator

Louis B. Justement, Ph.D.
Associate Director
Medical Scientist Training Program

Mailing address:

SHEL 502

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

 Telephone: 205- 934-1429

Fax: 205-934-1875

E-mail: lbjust@uab.edu

Postdoctoral Position Available

Analysis of the Molecular and Functional Role of the Transmembrane Receptor Trem-Like Transcript 2 (TLT2)

The genes encoding mouse and human TLT2 were cloned in our laboratory. Subsequent experiments demonstrated that TLT2 is expressed on B cells, neutrophils and macrophages. With respect to the B lineage, TLT2 is expressed early during development, prior to the BCR and can be detected on both fetal liver- and bone marrow-derived B cell progenitors. Although TLT2 is expressed on all B cells in the periphery, its level is higher on transitional, marginal zone and B-1 B cells when compared to follicular B cells. Expression of TLT2 can be detected on peritoneal and alveolar macrophages but not on monocytes in the blood. Finally, TLT2 is expressed on neutrophils and neutrophil progenitors. Importantly, TLT2 is significantly up-regulated on macrophages and neutrophils in response to inflammatory stimuli such as LPS or Staphylococcal superantigens. Neutrophils also contain large pools or preformed TLT2 in their granules that are rapidly released in response to activating stimuli such as FMLP or PMA. Thus, TLT2 is likely to play an important role in the innate immune response and is likely to functionally bridge components of the innate response with the adaptive response. Future studies will be conducted to:

1) Assess the functional role played by TLT2 in immune responses to infectious organisms; conditional knockout mice will be generated for these studies

2) Identify the ligand(s) for TLT2 using several molecular and biochemical approaches

3) Identify interacting signal transduction proteins and their associated pathways that mediate the functional effects of TLT2 on immune cells

Publications:

1. King, R.G., Herrin, B.R., and Justement, L.B. Trem-Like Transcript 2 (TLT2) is Expressed on Cells of the Myeloid/Granuloid and B Lymphoid Lineage and is Upregulated in Response to Inflammation. J. Immunol. 176: 6012; 2006.

Mentor/Principal Investigator

Louis B. Justement, Ph.D.
Associate Director
Medical Scientist Training Program

Mailing address:

SHEL 502

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

 Telephone: 205- 934-1429

Fax: 205-934-1875

E-mail: lbjust@uab.edu

Postdoctoral Position Available

Analysis of Virulence Factors Produced by Mycobacterium tuberculosis

Mycobaterium tuberculosis (MTb) is a serious world-wide pathogen that has the ability to survive within host phagocytic cells such as macrophages (MØ). It has been shown that virulent strains of MTb actually secrete a wide range of proteins or virulence factors that presumably alter host cell function. Studies are ongoing to examine the functional role of two secreted virulence factors produced by MTb. The first protein being studied is a protein tyrosine phosphatase called mPtpb. This phosphatase is secreted by MTb into the host MØ where it alters host cell function presumably by dephosphorylating one or more substrates. Ongoing studies in the lab are designed to:

1) Identify the mechanism responsible for secretion of mPtpb from MTb.

2) Identify the subcellular location of mPtpb in MØ as well as host cell proteins that interact with the phosphatase

3) Determine the effect that mPtpb has on MØ function

Studies have determined that mPtpb interacts with another protein that is secreted by MTb called enhanced intracellular survival (Eis) protein. Analysis of Eis structure suggests that this protein may function as an acetyltransferase. Recent work in our laboratory has confirmed that Eis is indeed an acetyltransferase enzye that can acetylate histone. Thus it possible that Eis regulates transcription in host MØ through its ability to acetylate one or more substrates in the cytoplasm or nucleus. Studies are being conducted to:

1) Study Eis acetyltransferase enzyme activity

2) Identify substrates in MØ that are acetylated by Eis

3) Determine the functional effect that acetylation of specific substrates has on MØ function

Mentor/Principal Investigator

 Peter E. Prevelige Jr., Ph.D.
Professor

 Mailing address:

BBRB 416

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2170

 Telephone: (205) 975-5327

Fax: (205) 975-5479

E-mail: prevelig@uab.edu

Mentor/Principal Investigator

Mark Walter, Ph.D.
Associate Professor

 Mailing address:

CBSE 144

1530 3RD AVENUE S

BIRMINGHAM AL 35294-4400

 Telephone: (205) 934-9279

Fax: (205) 934-0480

E-mail: walter@uab.edu

Mentor

 John F. Kearney, Ph.D.
Professor

Mailing address:

WTI 378

1530 3RD AVENUE S

BIRMINGHAM AL 35294-3300

Telephone: (205) 934-6557

Fax: (205) 934-1875

E-mail: jfk@uab.edu

Mentor

Dr. Allan J. Zajac
Assistant Professor

 Mailing address:

BBRB 446

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2170

 Telephone: (205) 975-5644

Fax: (205) 975-5645

E-mail:azajac@uab.edu

Contact

Molly Anne Moran

Program Manager II

Center for Neurodegeneration and Experimental Therapeutics

Department of Neurology

 CIRC 516

BIRMINGHAM AL 35294

 Telephone: (205) 996-6329

Fax: (205) 996-6580

E-mail: mmoran@uab.edu

Postdoctoral Position Available

A postdoctoral position is available in the brand new Center for Neurodegeneration and Experimental Therapeutics to study the molecular basis of Parkinson's disease. The available position will focus on developing models of neurodegeneration using the latest technologies in viral transduction and in vivo systems, with emphasis on the LRRK2 protein. Model systems will be adapted and applied to high-throughput screens in conjunction with the Southern Research Institute to discover small molecules capable of mitigating pathogenic processes.

Requirements: Candidate should have a Ph.D. or equivalent with a strong research background as evidenced by at least two first author publications in peer-reviewed English journals. The Center for Neurodegeneration and Experimental Therapeutics is a growing and dynamic group that requires exceptional interpersonal skills and high proficiency in written and spoken English.

Contact: Please send curriculum vitae, statement of current research and long-term goals (one page) and names and contact information of three references to: Molly Anne Moran

Center for Neurodegeneration and Experimental Therapeutics web site www.uab.edu/CNET

Mentor

Dr. Yuqing Li
Associate Professor

 Mailing address:

CIRC 545

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0021

 Telephone: (205) 996-6299

Fax: (205) 996-7200

E-mail: yli@uab.edu

Postdoctoral Positions

Postdoctoral positions in molecular and translational neuroscience are available immediately to study pathophysiology of dystonia and to develop siRNA-based therapeutic treatment for DYT1 dystonia using genetically modified mouse models (Dang et al., Experimental Neurology, 196:452-463, 2005; Dang et al., Neuroscience Research, 56:470-4, 2006; Dang et al., PNAS USA, 103:15254-9, 2006; Hewett et al., PNAS USA, 104:7271-7276).

Dystonia is defined clinically as involuntary, often sustained co-contraction of agonist and antagonist muscles causing abnormal and often painful postures or movements. It is generally believed to be mediated by the central nervous system and represents the third most common movement disorders after Parkinson's disease and tremor. The project involves using transgenic mouse models to study pathophysiology of dystonia/Parkinson disease and using siRNA/shRNA and pharmacological reagents to develop effective treatments for dystonia and other related movement disorders.

Highly motivated candidates with solid publication record in reputable journals in the area of molecular biology, cell biology, histology, cell culture, or mouse behavioral analysis are encouraged to apply. Experience in molecular or cell biology is desirable and knowledge in neuroscience or neurology is a plus. To apply, please send a statement of research interests, CV, and names and contact addresses of references to: Dr. Yuqing Li, Department of Neurology, School of Medicine, University of Alabama at Birmingham, 560 Civitan International Research Center, 1719 6th Avenue South, Birmingham, AL 35294-0021.

The Department of Neurology and the University of Alabama at Birmingham have established a Center for Neurodegeneration and Experimental Therapeutics, a state-of-art facility to accelerate discovery and to bring treatment to patients. Further, a new Comprehensive Neuroscience Center was established earlier this year and it provides advanced research services and extensive inter-disciplinary interactions. Further information about Dr. Li, the UAB Department of Neurology, and the Center for Neurodegeneration and Experimental Therapeutics, the Comprehensive Neuroscience Center, and related information about training environment may be found at the following Web sites:

http://main.uab.edu/neurology/Templates/Inner.aspx?pid=99179

http://www.uab.edu/postdocedu/

http://www.cnc.uab.edu/

Nutrition Sciences
and Medicine

Mentor

 Douglas C. Heimburger, MD, MS, FACP
Professor and Fellowship Director

Mailing address:

WEBB 439

1530 3RD AVENUE S

BIRMINGHAM AL 35294-3360

 Telephone: (205) 934-7058

Fax: (205) 934-7050

 E-mail: dheimbur@uab.edu

Mentor

Judith A. Kapp, Ph.D.
Professor

R. Pat Bucy, M.D., Ph.D.
Professor

Mailing address:

THE UNIVERSITY OF ALABAMA AT BIRMINGHAM

620 19TH STREET SOUTH

BIRMINGHAM AL 35233

E-mail: jkapp@uab.edu

 E-mail: Bucy@uab.edu

Postdoctoral Position Available

Cellular and Transplantation Immunology

We are recruiting for a postdoctoral fellow for NIH funded studies of immune regulation in cell and organ transplantation using genetically manipulated strains of mice. Highly motivated candidates with an MD and/or PhD degree and research experience in T cell Biology, immune regulation, transplantation immunology, and/or molecular immunology are encouraged to apply. Applicants should be willing to work in a team approach with good interpersonal skills and possess a strong work ethic. Excellent English and legal approval to work in the USA are required. Candidates who are interested in this position should submit their curriculum vitae, bibliography and three letters of recommendation to:

Judith A. Kapp, Ph.D. or R. Pat Bucy, M.D., Ph.D.

Mentor

Hui Wu, Ph.D.
Assistant Professor

Mailing address:

UAB SCHOOL OF DENTISTRY

LHRB 241

1530 3RD AVENUE SOUTH

BIRMINGHAM AL 35294-2170

Telephone: (205) 996-2392

Fax: (205) 975-6251

E-mail: hwu@uab.edu

Postdoctoral Position Available

A postdoctoral position is available for a self-motivated individual to investigate a newly identified biogenesis pathway for a bacterial adhesin. Studies will involve application of molecular biology, biochemistry and glycobiology approaches to define an important bacterial pathogenesis mechanism. Experience with biochemistry and/or bacterial genetics is highly desirable. Interested candidates please send your resume including past and current research activities, names, phone numbers and e-mail addresses of three references to: Hui Wu, Ph.D.

Mentor

Joseph L. Messina , Ph.D.
Associate Professor

Mailing address:

VH G019J

1530 3RD AVENUE SOUTH

BIRMINGHAM AL 35294-0019

Telephone: (205) 934-4921

Fax: (205) 975-1126

E-mail: messina@path.uab.edu

Mentor

Joanne Murphy-Ullrich, Ph.D.
Professor

 Mailing address:

VH 668B

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0019

Postdoctoral Position Available

Postdoctoral position available for person experienced in animal models to study the effectiveness of a peptide antagonist of TGF-ß activation in the treatment of a mouse model of diabetic nephropathy. This position, funded by the Juvenile Diabetes Research Foundation, is available beginning October 1, 2006. This position will entail administration of peptide, performing uninephrectomy surgery, sampling of blood and urine, and performing dermal wound healing studies. Immunohistochemical and morphometric analyses of tissues will also be performed.

Qualified candidates should send a CV and names of references to:

Dr. Joanne Murphy-Ullrich

Mentor

Majd Zayzafoon, M.D., Ph.D.
Asst. Professor

 Mailing address:

Shelby 813

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2182

 Telephone: (205) 934-5574 lab 205-996-9960

Fax: (205) 996-6119

E-mail: mzayzafoon@uab.edu

Mentor

Candece L. Gladson, M.D.
Professor

 Mailing address:

LHRB 567

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0007

 Telephone: (205) 975-7847

Fax: (205) 934-7346

E-mail: gladson@uab.edu

Mentor

Robin G. Lorenz, M.D., Ph.D.
Associate Professor

 Mailing address:

BBRB 730

1530 3RD AVENUE S

BIRMINGHAM AL 35294-2170

 Telephone: (205) 934-0676

Fax: (205) 975-8310

E-mail: rlorenz@uab.edu

Mentor

Zdenek Hel, Ph.D.
Assistant Professor

 Mailing address:

SW 287

619 19 TH STREET S

BIRMINGHAM AL 35249-7331

 Telephone: (205) 975-7079

Fax: (205) 975-7074

E-mail: zhel@path.uab.edu

Mentor

Coral Lamartiniere, Ph.D.
Professor

Mailing address:

VH 124

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0019

Telephone: (205) 934-7139

E-mail: Coral@uab.edu

Postdoctoral Position Available
Department of Pharmacology and Toxicology

A research position at the postdoctoral level is available in the laboratory of Dr. Coral A. Lamartiniere, Professor in Pharmacology and Toxicology and Senior Scientist in UAB's Comprehensive Cancer Center. Our laboratory relies on transgenic and chemically induced-rodent mammary and prostate models for determining how nutritional and environmental chemicals such as genistein, resveratrol, (-)-epigallocatechin-3-gallate (EGCG), TCDD, butyl benzyl phthalate, Bisphenol A, etc. can alter susceptibility for mammary and prostate cancers. We are interested in endocrine programming and DNA methylation mechanisms. Our lab places emphasis on studying the effects of these chemicals on protein expression of sex steroid receptors, coregulators and growth factor receptors and ligands using western blot analysis, immunohistochemistry, ELISA, etc. More recently, we have invested in proteomic technology (2D-gels and mass spec) to reveal novel proteins and functional proteomics. Also, we are interested in using proteomics for enriching and identifying biomarkers from blood and mammary interstitial fluid. Our laboratory is well funded by NIH and DOD grants, minimally through 2010. The researcher would have access to state of the art technology in our laboratory and in core facilities (proteomics, mass spectrometry, genomics, real-time PCR, pathology services, biostatistics/bioinformatics etc.) and be encouraged to interact with other researchers on campus. We welcome new technology and research ideas. This is an excellent opportunity to publish and develop an academic/research career. Salary will be consistent with NIH guidelines. Living expenses in Birmingham are moderate.

Applicants should send curriculum vitae and three references to Dr. Coral Lamartiniere.

Mentor

Charles N. Falany, Ph.D.
Professor

Mailing address:

VH G133M

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0019

Telephone: (205) 934-9848

E-mail: cfalany@uab.edu

Mentor :

Chris Lawson, Ph.D.
Department of Physics

 Mailing address:

CH 310

1530 3RD AVENUE SOUTH

BIRMINGHAM AL 35294-1170

E-mail: Lawson@uab.edu  

Physiological
Optics

Mentor :

 Steven J. Pittler, Ph.D.
Professor of Physiological Optics

 Mailing address:

WORB 658

1530 3RD AVENUE SOUTH

BIRMINGHAM AL 35294-4390

 Telephone: (205) 934-6744

Fax: (205) 934-5725

 E-mail: pittler@uab.edu

Physiological
Optics

Mentors:

 Roswell R. Pfister, M.D.

E-mail: rpfister@hiwayy.net

Om P. Srivastava, Ph.D.

E-mail :srivasta@uab.edu

Mentor

Kevin Kirk, Ph.D.

Department of Physiology & Biophysics

 Mailing address:

MCLM 982B

1530 3RD AVENUE SOUTH

BIRMINGHAM AL 35294-0005

E-mail: klkirik@uab.edu

Postdoctoral Position Available

To study the CFTR chloride channel that is implicated in cystic fibrosis and secretory diarrhea. Current projects include; (i) structure-function analysis of CFTR channel regulation and (ii) development of mouse knock-out/knock-in models to explore the functional relevance of protein-protein interactions involving CFTR. Expertise in patch champing our mouse genetics preferred. Highly motivated individuals will have the opportunity to learn new techniques and to submit independent grant proposals. Contact: Kevin L. Kirk, Ph.D., Department of Physiology and Biophysics, University of Alabama at Birmingham, 982B MCLM, Birmingham, AL 35294-0005. E-mail: klkirk@uab.edu.

Mentor

Lisa M. Schwiebert, Ph.D.

Department of Physiology & Biophysics

 Mailing address:

MCLM 955

1530 3RD AVENUE SOUTH

BIRMINGHAM AL 35294-0005

E-mail: lschwieb@uab.edu

Postdoctoral Position Available

"Effects of aerobic exercise on asthma-related responses"

A postdoctoral position is available to study the effects of aerobic exercise on asthma-related responses, including airway inflammation, Th cell responses, and lung function. Systems utilized in these studies include transgenic animal models, mechanical ventilation, primary cell culture, biochemical techniques, and confocal microscopy. Highly motivated applicants with research experience in Physiology, Immunology, Cell Biology or a related field are encouraged to apply. Two years of funding are available. Salary and benefits will be commensurate with experience and in accordance with NIH and UAB guidelines. Interested individuals should send a curriculum vitae and the names and contact information of three references to: Lisa M. Schwiebert, Ph.D., Department of Physiology & Biophysics

Mentor

Dale J. Benos, Ph.D.

Department of Physiology & Biophysics

 Mailing address:

Attn: Kay Guidry

MCLM 701

1918 University Blvd

BIRMINGHAM AL 35294-0005

Telephone: (205) 934-6220

Fax: (205) 934-2377

Postdoctoral Positions Available

Postdoctoral positions funded through a NIH NRSA training grant are currently available to prepare trainees for careers in cell and molecular physiology. Candidates must be a U.S. citizen or permanent resident, and have a Ph.D. or M.D with an interest in membrane transport processes. Women and underrepresented minorities are strongly encouraged to apply. Send a current CV., a letter describing research interests, and three references to : Dr. Dale Benos, Attn: Kay Guidry, University of Alabama at Birmingham, MCLM 701, 1918 University Blvd, Birmingham, AL 35294-0005.

The University of Alabama at Birmingham is an Affirmative Action/Equal Opportunity Employer.

Mentor

Erik M. Schwiebert, Ph.D.

Department of Physiology & Biophysics

 Mailing address:

MCLM 740

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0005

Telephone: (205) 934-6234

Fax: (205) 934-1445

E-mail: issytman@uab.edu

Postdoctoral Fellowship in Pancreatic Beta Cell and Islet Physiology and Pathophysiology Available Immediately

Projects in the laboratory of Dr. Erik Schwiebert, Ph.D. focus on purinergic receptor channels that act as calcium entry channels (the P2X receptor channels) gated by extracellular zinc and ATP as well as other cell calcium regulatory mechanisms. We are known more prominently for our work in normal airway and renal epithelia and how it goes awry in cystic fibrosis (CF) and polycystic kidney disease (PKD).

Recently, we have begun an analysis of the expression and function of P2X receptor channels on normal pancreatic beta cells and on primary islets from mouse and rat. We wish to extend these studies to human islets in the near future. We also wish to assess endogenous zinc and ATP secretion in concert with insulin as well as the possible benefits of these autocrine factors for beta cells of islets.

A postdoctoral fellowship is available immediately to contribute to this beta cell and islet project. We would like this fellow to begin work in January, February or March of 2007. Preference will be given to an electrophysiologist with some documentation of such training and with a Ph.D. degree or the equivalent.

Please forward via e-mail, a curriculum vitae and short well-written statements as to (1) how your training fits with our laboratory and of (2) your long-term research goals. Please also arrange 3 letters of reference to submitted to me. If a foreign applicant, please arrange a letter of reference from a colleague in the USA who knows of you and your work.

Preventive
Medicine

Program Director,

Catarine I. Kiefe, PhD, MD  

Contact

Suzanne Baker, RN, MPH
Deputy Director

UAB Center for Outcomes and Effectiveness Research and Education (COERE)

 Mailing address:

MT 521

1530 3RD AVENUE S

BIRMINGHAM AL 35294-4410

Telephone: (205) 934-6844

Fax: (205) 934-4888

E-mail: sbaker@uab.edu

A National Research Service Award Institutional Training Grant (T32)

Sponsored by

The Agency for Healthcare Research and Quality (AHRQ)

Research training for this program involves a collaboration between the UAB Center for Outcomes and Effectiveness Research and Education <http://www.dopm.uab.edu/coere/index.html> and the UAB Lister Hill Center for Health Policy <http://www.soph.uab.edu/default.aspx?id=34>, offering a core of experienced mentors with extensive expertise and funding track records in health services research.

Program Content Areas:

• Translating Research into Practice (TRIP)
• Health Outcomes Research
• Quality Measurement
• Economic Evaluation

Goal: The overall goal of the program is to prepare independent investigators to pursue health services research careers focused on translating research evidence into practice.  Among the research areas targeted for development are: changing physician practice behavior, improving quality of care, and assessing the impact of the delivery system on the quality of care. Skills development will include exposure to relevant epidemiological, statistical, experimental, and quasi-experimental methodologies, analysis of large data sets, health outcomes assessment, and economic evaluation, all with an emphasis on the practical application of outcomes research methodology in translating research into practice.

Requirements & Eligibility: The academic components of the program involve the MSPH in Outcomes Research from the UAB School of Public Health, Department of Health Care Organization and Policy for clinician-postdoctoral trainees, and the PhD in Health Services Administration-Health Services Research Track from the School of Health-Related Professions, Department of Health Services Administration for predoctoral trainees. Postdoctoral training requires a 2-year commitment. To be eligible all candidates must be U.S. Citizens or have permanent residence status. In addition, postdoctoral candidates must have a clinical doctoral degree (MD, DDS/DMD, Nursing PhD, PhD in Clinical Psychology, PharmD), and predoctoral candidates must be accepted into the PhD program in Health Services Administration-Health Services Research. Applications are reviewed throughout the year. The program is currently funded for 3 postdoctoral slots with 1-2 openings per year.

Psychiatry and

Behavioral Neurobiology

Mentor

Xiaohua Li, M.D., PhD
Associate Professor

Department of Psychiatry & Behavioral Neurobiology

 Mailing address:

SC1075

1530 3RD AVENUE S

BIRMINGHAM AL 35294-0018

 Telephone: (205) 934-1169

Fax: (205) 934-2500

 E-mail:xili@uab.ed

Postdoctoral Position Available
A postdoctoral position is immediately available in the Department of Psychiatry. The postdoctoral research will focus on the molecular biology of mood disorders, such as bipolar disorder and depression, aiming to identify the pathophysiology of mood disorders and the molecular mechanisms of action of mood disorder treatment. 
Individuals who have research background in the molecular biology, immunocytochemistry, primary neuronal culture, and animal genotyping and behavior tests, and are high motivated to be on the cutting edge of a translational research field are encouraged to apply. Criteria for selection include demonstrated research ability and experience in relevant research areas, skills in verbal and written communication, and genuine commitment to the research project. Salary is in line with NIH levels.

Radiation Oncology

Mentor

 James A. Bonner, M.D.
Chairman

Department of Radiation Oncology

 Mailing address:

WTI 102

1530 3RD AVENUE S

BIRMINGHAM AL 35294-3300

 Telephone: (205) 934-2761

Fax: (205) 934-5184

 E-mail:jabonner@uab.edu

Principal Investigator & Leader

Karl Heinz Braunewell , Ph.D.

Molecular & Cellular Neuroscience Laboratory

 Mailing address:

Southern Research Institute

2000 9th Avenue South

Birmingham, AL 35205

 Telephone: (205) 281-2864

Postdoctoral Scholar Position Available

Immediate postdoctoral opportunity to study the roles of calcium sensor proteins in neuronal signaling pathways. The Molecular and Cellular Neuroscience Lab is studying calcium sensors relevant for hippocampal physiology as well as neurological diseases with interdisciplinary approaches. Ph.D. in molecular biology, biochemistry, cell biology, neurosciences or relevant discipline required. We are seeking a highly motivated candidate with general background in neuroscience. Expertise in molecular biology, neurochemistry, primary neuronal cultures, immunocyto- and histochemistry preferred. Interested applicants should send their detailed curriculum vitae that includes research interests, publication list and contact information for three references to braunewell@sri.org.

Southern Research Institute a UAB Associate Company

Principal Investigator & Leader

Bo Xu, M.D., Ph.D.

Laboratory of Molecular Radiobiology

 Mailing address:

Southern Research Institute

2000 9th Avenue South

Birmingham, AL 35205

 Telephone: (205) 281-2845

Postdoctoral Scholar Position Available

Immediate postdoctoral research opportunity is available in the Molecular Radiobiology Laboratory requiring a Ph.D. degree in Molecular Biology, Biochemistry, Genetics or relevant discipline. Experience in molecular cloning, mutagenesis, and protein purification is desirable. The successful candidate will perform research projects focused on understanding the basic mechanisms of the cellular response to DNA damaging agents. We are seeking candidates who are self-motivated and career-oriented to join an exciting highly interactive research team. Please send your CV and a cover letter to xu@sri.org if you are interested.

Contact:

Dr. Irshad H. Chaudry
Professor and Director

Center for Surgical Research

 Mailing address:

1670 University Blvd

Volker Hall G094

Birmingham, AL 35294-0019

 Telephone: (205) 975-2195

Fax: (205) 975-9719

E-mail: Irshad.Chaudry@ccc.uab.edu

NRSA RESEARCH FELLOWSHIP in TRAUMA and INFLAMMATION

APPLICATION DEADLINE: January 5, 2007
for the July 1, 2007 positions

NSRA fellowships are available for research training in the areas of trauma, burn, surgical critical care and inflammation. Trainees will pursue a two-year research program in the laboratory of an established basic and clinical research scientist, supplemented with training in advanced biostatistics and bioethics courses.

The trainees will be required to carry out an independent research project in the laboratory of an accomplished basic scientist experienced in physiology, pathology, microbiology, immunology, molecular biology, or epidemiology with guidance provided by a clinical mentor in trauma, burns or surgical clinical care. The faculty is drawn from established investigators in the medical school. Current areas of research interest include cardiovascular biology, immunology, trauma, burns, inflammation, sepsis, gender dimorphism, apoptosis, and wound healing. This training program is designed to provide research training for clinicians and basic scientists who are interested in pursuing academic careers in trauma and inflammation-related disciplines.

Selection of trainees is based on the demonstrated ability of the candidate and his/her career choice in academic medicine. Applicants must be United States citizens or permanent residents and have completed their MD, PhD or DVM. The MD candidates must have at least two years of post-doctoral experience (Residency training). Those candidates pursuing a Fellowship during their clinical training program must provide evidence that they will be accepted back into that clinical program upon completion of this Fellowship training. Interested applicants are encouraged to submit curriculum vitae, three letters of recommendation and a personal statement detailing their career interests.

The University of Alabama at Birmingham is an equal opportunity employer and applications from qualified under-represented minorities and women are strongly encouraged. The Program Directors, Basic Science and Clinical Science coordinators and selected faculty members will interview the finalist candidates and the Executive Committee will select the trainees.

SUPPORT : Includes stipend, benefits, tuition for courses at School of Medicine, travel funds, and appointment at the School of Medicine as a Post-Doctoral Fellow

CONTACT : Dr. Irshad H. Chaudry, Professor and Director, Center for Surgical Research, Volker Hall G094, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, Alabama 35294-0019;  Phone (205) 975-2195   Fax (205) 975-9719   E-mail Irshad.Chaudry@ccc.uab.edu

NIH/NIGMS POST-DOCTORAL TRAINING IN TRAUMA and INFLAMMATION RESEARCH

UNIVERSITY of ALABAMA at BIRMINGHAM

PROGRAM FACULTY MENTORS & RESEARCH INTERESTS

Dale J. Benos, Ph.D.
Professor and Chairman
Physiology & Biophysics
                               
Elucidation of the molecular basis for operation of epithelial and atrocyte ion channels and transporters, and understanding the role of cytokines and HIV envelope protein, gp120, on the atrocyte ion transport function; calreticulin function and elucidation of transcription mechanisms in glucocorticoid-mediated adipocyte differentiation in stromal cells         

Etty N Benveniste, Ph.D.
Professor and Chairperson
Cell Biology

Cytokine and chemokine regulation of gene expression in central nervous system, especially in astrocytes and glial cells

Antihypertensive drugs and the effects of interruption of renin-angiotensin receptor interactions in hypertension pathophysiology

Understanding the mechanism for transcriptional regulation of neurotransmitters and role of hypothalamus pituitary-adrenal axis on immune functions

Kirby I Bland, M.D.
Professor and Chairman
Surgery

Dietary fat reduction and systemic adjuvant therapy in the management of patients with primary invasive breast cancer; Taxol and radiation therapy for marginally resectable stage IIIA non-small cell lung cancer; adjuvant Tamoxifen therapy in old age; colorectal carcinoma clinical trials; cardiovascular and immunological aspects of trauma-hemorrhage

Irshad H Chaudry, Ph.D.
Professor and Vice-Chairman
Surgery

Maintenance of organ function after trauma-hemorrhage, immunological aspects of hemorrhage as well as sepsis, with particular emphasis on gender dimorphism and modulation of the depressed cardiovascular and immunological responses with novel therapeutic modalities

Max D Cooper, M.D.
Professor
Developmental & Clinical Immunology

The mechanisms of differentiation of hemopoietic progenitor cells

Pre-clinical and clinical evaluation of immunosuppressive agents

Charles O Elson, M.D.
Professor
Medicine

Regulation of mucosal responses, maintenance of normal homeostasis and contribution to chronic intestinal inflammation

William E Grizzle, M.D., Ph.D.
Professor
Pathology

Solid tumors focusing on the identification of biomarkers associated with preinvasive and advanced malignant lesions

Evaluation of chemopreventive agents in chemically induced cancer models

Mark N Hadley, M.D.
Professor
Neurosurgery

Treatment of spasticity following remote head and spinal cord injury

William M Holman, M.D.
Professor
Surgery

Support and treatment for resolution of acute heart failure

Delineating cellular and molecular mechanisms in the development of T and B lymphocytes

The role of immune system in chronic inflammatory diseases such as lupus erythematosus as well as the receptors for immunoglobulin in phagocyte functions

Understanding the basic mechanisms responsible for: a) active ion transport across the normal and injured epithelium; b) killing of pathogen by mammalian lung; and c) oxidant injury to the pulmonary surfactant system in vivo and in vitro

Jay M McDonald, M.D.
Professor and Chairman
Pathology

The intracellular signal transduction pathways that transfer key information from extracellular to intracellular environment leading to coordinated cellular responses

Gerald McGwin Jr., Ph.D.
Assistant Professor
Surgery

The area of epidemiology; focused on the cause, outcome and recurrence injuries caused by trauma and burn

Joseph L Messina, Ph.D.
Associate Professor
Pathology

Understanding the mechanisms by which hormones and growth factors regulate genes involved in cell growth and metabolism

Suzanne M Michalek, Ph.D.
Professor
Microbiology

The mucosal immune system; the development of mucosal vaccines for the induction of protection immunity and host mechanisms associated with inflammation of periodontal disease

Larry W Moreland, M.D.
Professor
Medicine

The evaluation of therapies and mechanisms of disease process in rheumatoid arthritis

Suzanne Oparil, M.D.
Professor
Medicine

Hormones and vasoprotection

Dale A Parks, Ph.D.
Professor
Anesthesiology, Physiology & Biophysics

Physiologic, biochemical and cellular mechanisms of reactive and nitrogen metabolism with special reference to ischemia-reperfusion and inflammatory states

Loring W Rue III, M.D.
Professor
Surgery

Understanding the role of Fibroblast Growth Factor I in bone remodeling and spinal cord repair

Martin G Schwacha, Ph.D.
Associate Professor
Surgery

Immune dysfunction following burn and trauma-hemorrhage with focus on macrophage and T-cell functions

Phillip D Smith, M.D.
Professor
Medicine

Elucidation of cascade of regulatory events that determine mucosal immune response to enteric pathogen and inflammatory stimuli

Judith M Thomas, Ph.D.
Professor
Surgery

Immunological tolerance to tissue and organ transplants

John A Thompson, Ph.D.
Professor
Surgery

The use of Fibroblast Growth Factor as a therapeutic agent in the promotion of site-specific angiogenesis, for enhancing wound healing and regeneration of peripheral nerves, damaged spinal cords, and the musculoskeletal system following traumatic injury

Contact

Carolyn Maddox
Administrative Associate for
Kirby I. Bland, M.D., Program Director and Pablo Arnoletti, M.D., Associate Program Director

Department of Surgery

 Mailing address:

2512 NORTH PAVILION

BIRMINGHAM AL 35294

 Telephone: (205) 934-2089

Fax: (205) 975-9875

E-mail: Carolyn Maddox

T32 RESEARCH TRAINING PROGRAM
IN SURGICAL ONCOLOGY

Applications due by April 30, 2007 for July 1, 2007 start date

The University of Alabama at Birmingham, Department of Surgery, announces that applications are being accepted for Research Training Fellowships for the Academic Year 2007-2008

• Two-year research training program
• Mentored multidisciplinary research projects
• Open to Residents (to follow PGY-2 year)
• Support includes stipend, benefits, tuition for courses at UAB Graduate School and travel funds

Applicants must be either U.S. Citizen or Permanent Resident

For further information please contact: Carolyn Maddox